Klaus Pfizenmaier,Peter Scheurich,Roland Kontermann,Sabine Muenkel
申请号：
US13765923
公开号：
US09045535B2
申请日:
2013.02.13
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a ligand, which specifically binds to human tumor necrosis factor type 1 receptor (huTNFR1). The ligand includes one or more amino acid sequences of human origin capable of reducing the immunogenic response of the ligand in humans and one or more amino acid sequences capable of selectively binding to huTNFR1. The present invention also relates to a nucleic acid sequence encoding the ligand and to a pharmaceutical composition for the treatment of disorders related to huTNFR1.
