The invention relates to a composition comprising engineered Natural Killer (NK) cells that express an adhesion receptor comprising an extracellular receptor domain that binds to a target cell antigen as well as a transmembrane domain to anchor the extracellular receptor domain on the surface of the NK cell. The NK cells expressing such adhesion receptor have enhanced ability to target specific cells, such as cancerous cells or those affected by an infectious disease. Several exemplified embodiments relate to NK cells expressing adhesion receptors comprising scFv that targets Her2 or PSMA cancer antigens, the NK cells exhibiting cytotoxic and/or cytolytic effects when the NK cells bind target cells.
