A compound represented by the formula (1) or a salt thereof (~ represents asingle bond, or a double bond； R1 represents hydrogen atom, or an alkyl group；R2 and R3represent hydrogen atom, or an alkyl group； R4 and R5 represent hydrogen atom,hydroxygroup, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substitutedamino group；R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxygroup； R7represents one or two of substituents on the benzene ring (the substituentsare selectedfrom hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group,aminogroup, an alkyl group, and an alkoxyl group)； A represents a 5-membered or 6-memberednon-aromatic heterocyclic ring containing one or two contiguous sulfur atoms(the sulfuratoms may independently form oxide)； W~ represents oxo group, hydrogen atom,analkyl group, hydroxy group, an alkoxyl group, or a halogen atom； and Xrepresents oxygenatom, or sulfur atom), or a salt thereof, which has a superior suppressingaction againstprostaglandin E2 production and is useful as an active ingredient ofmedicaments withreduced adverse reactions such as gastrointestinal disorders.(see formula 1)
