An endoscope defogging and pre-heating device includes a bag including a first seal line and first and second chambers defined at an opposite lateral sides relative to the first seal line, a heat storage/release material flowing between the first chamber and the second chamber for storing/releasing heat energy, a fixation device for securing the bag in a folded status to hold the endoscope to be pre-heated between the first and second chambers, and an actuator bendable to generate oscillation waves for causing the heat storage/release material to produce a temperature rise and then to release heat for pre-heating the loaded endoscope to about 98° F.˜138° F.
