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3-(2-dimethylaminomethyl cyclohexyl) phenol retard formulation
专利权人:
Grunenthal GmbH
发明人:
Bartholomaus, Johannes,Jung, Tobias
申请号:
AU2006291422
公开号:
AU2006291422B2
申请日:
2006.09.15
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention relates to a form of administration for the controlled releasingof the active substance 3-(2-dimethylaminomethyl cyclohexyl) phenol, preferably(1R,2R)-3-(2-dimethylaminomethyl cyclohexyl) phenol, or one of the pharmaceuticallyacceptable salts thereof. Said form of administration (i) in vivo reaches thepeak plasma level of the active substance after 2 to 10 h, and/or (ii) in vitro releases3.0 to 37 percent by weight of the active substance originally contained thereinafter 05 hours, 5.0 to 56 percent by weight after 1 hour, 10 to 77 percent by weightafter 2 hours, 15 to 88 percent by weight after 3 hours, at least 30 percent by weightafter 6 hours, at least 50 percent by weight after 12 hours, at least 70 percentby weight after 18 hours, and at least 80 percent by weight after 24 hours when measuredaccording to the European pharmacopoeia by means of a blade mixer in buffer solutionat a pH value of 6.9 (preferably 900 ml), a temperature of 37 °C, and 75 U/min.
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