ATKINSON, Stephen John,BARKER, Michael David,CAMPBELL, Matthew,DIALLO, Hawa,DOUAULT, Clement,GARTON, Neil Stuart,LIDDLE, John,SHEPPARD, Robert John,WALKER, Ann, Louise,WELLAWAY, Christopher,WILSON, Da
申请号：
DK12740581
公开号：
DK2877467T3
申请日:
2012.07.26
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
Compounds of formula (I): wherein； R1 is hydrogen or C1-6alkyl； R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O&mdash；, or C1-6alkoxy； R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl； R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl； or unsubstituted C3-6cycloalkylC1-6 alkyl； A is C&mdash；R5 or N； B is C&mdash；R6 or N； D is C&mdash；R7 or N； with the proviso that at least one of A, B, and D, is N； R5 is hydrogen or C1-6alkyl； R6 is hydrogen or C1-6alkyl； R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy； R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen； R9 is hydrogen or hydroxy； R10 is hydrogen or C1-6alkyl； and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.
