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Compounds
专利权人:
BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
Kai Thede,William Scott,Eckhard Bender,Stefan Golz,Andrea Hägebarth,Philip Lienau,Florian Puehler,Daniel Basting,Dirk Schneider,Manfred Möwes,Anja Richter,Ludwig Zorn,Ningshu Liu,Ursula Mönning,Franzi
申请号:
US14778568
公开号:
US10130633B2
申请日:
2014.03.17
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease such as cancer, wherein i.a.: LA represents an optionally substituted methylene or ethylene group; LB represents —N(H)—C(═O)— or —C(═O)—N(H)—; R1 represents an optionally substituted 5- to 8-membered heterocycloalkyl, 4- to 10-membered heterocycloalkenyl, aryl, heteroaryl or —N(R7)(Ci-C6-alkyl) group; R2 represents an optionally substituted 5- or 6-membered heteroaryl group; R3 represents an optionally substituted phenyl group.
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