The subject matter of the invention relates to therapy wraps for the application of compression and/or thermal therapy to a patient. The wraps are formed of at least two layers of material which are sealed together to form at least one cavity between them. At least two layers of the wrap are sealed together using a plurality of different seal patterns. A first seal pattern is provided in at least one zone. The zone is surrounded by a perimeter seal, an internal seal or at least one different seal pattern or a combination thereof. The pattern within the zone or zones provides higher volume fluid flow paths than the pattern or patterns surrounding the zone or zones.