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ION CHANNEL MODULATORS AND METHODS OF USE
专利权人:
VERTEX PHARMACEUTICALS INCORPORATED
发明人:
MARTINBOROUGH, ESTHER,NEUBERT, TIMOTHY,WHITNEY, TARA,LEHSTEN, DANIELLE,KNOLL, TARA,ZIMMERMANN, NICOLE,TERMIN, ANDREAS
申请号:
NZ58130908
公开号:
NZ581309A
申请日:
2008.05.21
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a 4-propanamido-phenylsulfonyl) carboxamide of formula I or a pharmaceutically acceptable salt thereof, wherein R1 and R1, R2 and R3 are defined in the specification for treating or lessening the severity of femur cancer pain non-malignant chronic bone pain rheumatoid arthritis osteoarthritis spinal stenosis neuropathic low back pain neuropathic low back pain myofascial pain syndrome fibromyalgia temporomandibular joint pain chronic visceral pain, including, abdominal pancreatic IBS pain chronic and acute headache pain migraine tension headache, including, cluster headaches chronic and acute neuropathic pain, including, post-herpetic neuralgia diabetic neuropathy HIV associated neuropathy trigeminal neuralgia Charcot-Marie Tooth neuropathy hereditary sensory neuropathies peripheral nerve injury painful neuromas ectopic proximal and distal discharges radiculopathy chemotherapy induced neuropathic pain radiotherapy-induced neuropathic pain post-mastectomy pain central pain spinal cord injury pain post-stroke pain thalamic pain complex regional pain syndrome phantom pain intractable pain acute pain, acute post-operative pain acute musculoskeletal pain joint pain mechanical low back pain neck pain tendonitis injury/exercise pain acute visceral pain, including, abdominal pain pyelonephritis appendicitis cholecystitis intestinal obstruction hernias etc chest pain, including, cardiac pain pelvic pain, renal colic pain, acute obstetric pain, including, labor pain cesarean section pain acute inflammatory, burn and trauma pain acute intermittent pain, including, endometriosis acute herpes zoster pain sickle cell anemia acute pancreatitis breakthrough pain orofacial pain including sinusitis pain, dental pain multiple sclerosis (MS) pain pain in depression leprosy pain Behcets disease pain adiposis dolorosa phlebitic pain Guillain-Barre pain painful legs and moving toes Haglund syndrome erythromelalgia pain Fabrys disease pain bladder and urogenital disease, includ
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