Systems and methods for a sterile radiological drape designed to isolate the non-sterile portions of medical equipment used during surgery from the sterile zone adjacent to where medical procedures are performed are described. In one embodiment the flexible sterile drape enclosure may be incorporated into the patient drape allowing for protection and draping of both the patient and the medical equipment. In another embodiment the drape comprises a board with a hole formed therein and a sterile enclosure mounted thereto atop of a Mayo stand. This hole allows for the medical equipment to rotate into the sterile enclosure in close proximity with the sterile zone without contaminating it. The systems and methods provide advantages in that the sterile drape is easy to apply and may be moved multiple times during the surgery, which reduces the length of a medical procedure as well as the cost associated therewith.