Julia Vile;Richard Edward Armer;Graham Michael Wynne;Colin Richard Dorgan;Carole Eliane Andree Maillol
发明人:
Richard Edward Armer,Carole Eliane Andree Maillol,Colin Richard Dorgan,Graham Michael Wynne,Julia Vile
申请号：
US12357821
公开号：
US08168673B2
申请日:
2009.01.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of general formula (I)whereinW is chloro or fluoro；Z is a group SO2R1；wherein R1 is —C3-C8 cycloalkyl or heterocyclyl optionally substituted with one or more substituents chosen from halo, —CN, —C1-C6 alkyl, —SOR3, —SO2R3, —SO2N(R2)2, —N(R2)2, —NR2C(O)R3, —CO2R2, —CONR2R3, —NO2, —OR2, —SR2, —O(CH2)pOR2, and —O(CH2)pO(CH2)qOR2 wherein each R2 is independently hydrogen, —C1-C6 alkyl, —C3-C8 cycloalkyl, aryl or heteroaryl；each R3 is independently, —C1-C6 alkyl, —C3-C8 cycloalkyl, aryl or heteroaryl；p and q are each independently an integer from 1 to 3；and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.
