Disclosed herein are compounds of formula (I) that may be specific to PPAR and/or EGF receptors, and methods of making and using same.wherein X is C1-C3alkylene, optionally substituted with one, two or three substituents selected from halogen or hydroxyl；R1 is selected from the group consisting of C1-C6alkyl, C3-C6cycloalkyl, C2-C6alkenyl, and C2-C6alkynyl；R2 is selected from the group consisting of hydrogen and C1-C6alkyl；R3 is independently selected, for each occurrence from the group consisting of hydrogen, C1-C6alkoxy, C1-C6alkyl, cyano, C3-C6cycloalkyl, halogen, hydroxyl, and nitro；R4 is selected from the group consisting of hydrogen and C1-C6alkyl；R5 is hydrogen C1-C6alkyl；or pharmaceutically acceptable salts or N-oxides thereof.
