CUIFEN HOU,DANA L. JOHNSON,HEATHER RAE HUFNAGEL,XUQING ZHANG,ZHIHUA SUI
申请号：
BRPI1016189
公开号：
BRPI1016189A2
申请日:
2010.04.15
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention comprises compounds of Formula (I): wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
