FEUERBACH, DOMINIK,FREDERIKSEN, MATHIAS,MARZI, MARTIN,ROY, BERNARD
申请号：
ES06806403
公开号：
ES2376890T3
申请日:
2006.10.19
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula (I) ** Formula ** in which X represents CH2； R represents a substituted or unsubstituted C5-C10 aryl, wherein the substituents are selected from the group consisting of amino, (C1-C4) -amino, di [(C1-C4) alkyl] -amino, (C3-cycloalkyl) -C5) -amino, di [cycloalkyl (C3-C5)] - amino, N-alkyl (C1-C4) -N-cycloalkyl (C3-C5) -amino, halogen, C1-C4 alkyl, C4-C6 cycloalkyl, hydroxy, C1-C4 alkoxy, C3-C5 cycloalkyloxy, (C1-C4) alkoxy (C1-C4) alkoxy, di [(C1-C4) alkyl] -amino (C1-C4) alkoxy, carbamoyl, N-alkyl (C1-C4) - carbamoyl, N, N-di [(C1-C4) alkyl] - carbamoyl, nitro, cyano, carboxy, (C1-C4) alkoxycarbonyl, C1-C4 alkanoyl, C1-C4 alkanoyloxy, benzoyl , amidino, guanidino, ureido, mercapto, (C1-C4) alkyl-thio, pyridyl, phenyl, phenoxy, (C1-C4) alkoxy-phenyl, phenylthio, phenyl-(C1-C4) alkylthio, (C1-) alkyl C4) -sulfonyl, phenylsulfonyl, (C1-C4) alkyl-phenylsulfonyl, C1-C4 alkenyl, C1-C4 alkanoyl, C1-C4 alkylenedioxy bonded to adjacent C ring atoms, and C1-C4 alkyl, which is substituted with halogen , hydroxy, C1-C4 alkoxy, nitro, cyano, carboxy, (C1-C4) alkoxycarbonyl, C1-C4 alkanoyl and C1-C4 alkanoyloxy； or R represents a substituted or unsubstituted C5-C10 heteroaryl, wherein the C5-C10 heteroaryl is an aromatic heterocyclic system comprising one, two or three heteroatoms selected from N, O and S； and wherein the existing substituents are being selected from the group consisting of amino, (C1-C4) -amino, di [(C1-C4)] -amino, cycloalkyl (C3-C5) -amino, di [cycloalkyl (C3-C5)] - amino, N-C1-C4 alkyl-N-cycloalkyl (C3-C5) -amino, halogen, C1-C4 alkyl, C4-C6 cycloalkyl, hydroxy, C1-C4 alkoxy, C3 cycloalkyloxy -C5, (C1-C4) alkoxy (C1-C4) alkoxy, di- [(C1-C4) alkyl] -amino (C1-C4) alkoxy, carbamoyl, N-(C1-C4) alkylcarbamoyl, N, N-di [(C1-C4) alkyl] - carbamoyl, nitro, cyano, carboxy, (C1-C4) alkoxy, carbonyl, C1-C4 alkanoyl, C1-C4 alkanoyloxy, benzoyl, amidino, guanidino, ureido, mercapto , (C1-C4) alkyl-thio, pyridyl, phenyl, phenoxy, (C1-C4) alkoxy-pheny
