WOLFF, HANS-MICHAEL H-M,‧沃爾夫,ARTH, CHRISTOPH C,‧阿爾斯,QUERE, LUC L,‧奎爾,MUELLER, WALTER W,‧米勒
申请号:
HK15100819.2
公开号:
HK1200335A
申请日:
2015.01.23
申请国别(地区):
HK
年份:
2015
代理人:
摘要:
The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.