UCB Biopharma SPRL;LTS LOHMANN Therapie-Systeme AG
发明人:
WOLFF Hans-Michael,ARTH Christoph,QUERE Luc,MULLER Walter
申请号:
SI201031744
公开号:
SI2515887T1
申请日:
2010.12.22
申请国别(地区):
SI
年份:
2018
代理人:
摘要:
The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.