Drink bottles, or containers, with bite-actuated mouthpieces. In some embodiments, the mouthpieces are self-sealing mouthpieces that are biased to return from a dispensing configuration to a closed configuration. The bottles may be rigid or collapsible and may include a removable cap assembly. In some embodiments, the bottles include a manual on/off valve adapted to prevent drink fluid from being dispensed regardless of the mouthpiece's configuration. In some embodiments, the bottles include a straw extending into the bottle and/or a drink tube extending from external of the bottle and/or an air return system. In some embodiments, the bottles include a dispensing spout that is pivotally coupled to the cap of the drink bottle. In some embodiments, the dispensing spout includes a mount for the mouthpiece and/or cooperates with the cap to provide a manual on/off valve to selectively restrict flow of drink fluid from the bottle regardless of the mouthpiece's configuration.