Di Paolo Julie,Hawkins Michael J.,Hu Jing,Jin Feng,Melchor-Khan Flordeliza,Reddy Anita
申请号：
NZ71882514
公开号：
NZ718825A
申请日:
2014.12.03
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof. The subject is a human who has a 17p deletion, a TP53 mutation, a NOTCH1 mutation, SF3B1 mutation, a 11q deletion or any combination thereof. The subject may be very high risk or high risk for the cancer. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a hematologic malignancy, such as leukemia or lymphoma.
