БУЕНСУКЕСО Чарито С. (US),КИХМ Энтони Дж. (US),ДХАНАРАДЖ Сридеви (US),АТЛАС Рои (IL),НУР Израэль (IL),МЕЙДЛЕР Роберто (IL),БАР Лилиана (IL)
申请号：
RU2014108878/15
公开号：
RU2014108878A
申请日:
2011.08.10
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of treating a patient having peripheral vascular disease, comprising administering a pharmaceutical composition comprising fibrin glue and an isolated homogeneous population of cells derived from human umbilical cord tissue in an amount effective to treat the disease, wherein the umbilical cord tissue is substantially free of blood, and wherein said isolated homogeneous population of cells is capable of self-renewal and propagation in culture, has the potential for differentiation and does not express CD117 and / or telomerase. 2. The method of claim 1, wherein the isolated cell population has one or more of the following characteristics: (a) expresses an oxidized low density lipoprotein receptor 1, a reticulon, a chemokine receptor ligand 3 and / or a granulocyte chemotactic protein； (b) does not express CD31, CD34 or CD45； (c) expresses, in relation to fibroblasts, mesenchymal stem cells or bone marrow cells of the human iliac crest, elevated levels of interleukin-8 or reticulon 1； (d) has the potential to differentiate into cells by less the least phenotype of skeletal muscle cells, vascular smooth muscle cells, perivascular cells or vascular endothelial cells； and (e) expresses CD10, CD13, CD44, CD73 and CD90.3. The method of claim 1, wherein the peripheral vascular disease is peripheral vascular ischemia. The method of claim 3, wherein the pharmaceutical composition is administered at the site of peripheral vascular ischemia. The method of claim 4, wherein the pharmaceutical composition is administered by intramuscular injection or injection into fat depots in the muscles. The method of claim 1, wherein the pharmaceutical composition is administered�1. Способ лечения пациента, имеющего заболевание периферических сосудов, включающий введение фармацевтической композиции, содержащей фибриновый клей и выделенную однородную популяцию клеток, полученных из ткани пуповины человека, в количестве, эффективном для лечения заболевания, причем ткань пуповины, п
