The present invention is directed to phenylamide and pyridylamide derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimers disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.Linvention porte sur des composés dérivant de la phénylamide et de la pyridylamide, inhibiteurs de la bêta-secrétase, et savérant utiles dans le traitement de maladies telles que celle dAlzheimer où la bêta-secrétase est impliquée. Linvention porte également sur des préparations pharmaceutiques comprenant ces composés et leur utilisation, et sur des préparations traitant de telles maladies.
