Hamid Mirzaei,Asish Ray Chaudhuri,Sivaramakrishna Yadavalli,Esmail Dehghan,Zhang Yiqiang,Tambar K. Uttam,Indumathy S. Subramaniyan,Maryam Dehghani,Bin Xu,Bahar Saremi
申请号：
US16085368
公开号：
US20190298717A1
申请日:
2017.03.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention includes a method of protecting or treating neural cells from degeneration comprising: identifying a neural cell in need of protection from at least one of radical oxidative stress, increased mitochondrial biogenesis, decreased intracellular protein aggregation or neurofibrillary tangles, increase of at least one of cellular NAD or ATP levels, activation of autophagy, removal of protein aggregates, prevents GSK3β or Tau protein phosphorylation, or increase neuronal plasticity； and providing the neural cell with a therapeutically effective amount of a hydralazine or active bioequivalent thereof sufficient to reduce radical oxidative stress, increase mitochondrial biogenesis, decrease intracellular protein aggregation or neurofibrillary tangles, increase of at least one of cellular NAD or ATP levels, activate autophagy, remove protein aggregates, prevent GSK3β or Tau protein phosphorylation, or increase neuronal plasticity, thereby protecting the neural cells from degeneration.
