PURPOSE: A composition for promoting differentiation from human mesenchymal stem cells into adipocytes is provided to enhance skin volume and elasticity ad to improve anti-wrinkling.CONSTITUTION: An external use skin composition for promoting adipocyte differentiation contains 0.0001-30 wt% of Chrysanthemi sibirici Herba extract as an active ingredient. The composition promotes the differentiation of human mesenchymal stem cells into adipocytes. A pharmaceutical composition for promoting adipocyte differentiation contains the extract as an active ingredient. The daily dose of the extract is 0.001mg/kg/day-2000mg/kg/day.COPYRIGHT KIPO 2012본 발명은 인간 중간엽줄기세포의 지방세포로의 분화를 촉진하는 조성물에 관한 것으로, 보다 상세하게는 구절초 추출물을 유효성분으로 함유하여 인간 중간엽줄기세포를 지방세포로 분화하는 것을 촉진시킴으로써 지방체 (Lipid droplet)를 생성하여 피부의 볼륨과 탄력을 증진시키고 주름을 개선시키는 조성물에 관한 것이다.
