SHIN, DONG WOOK,신동욱,NOH, MIN SOO,노민수,PARK, SOO NAM,박수남
申请号：
KR1020110060194
公开号：
KR1020120140450A
申请日:
2011.06.21
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A composition with Nelumbinis Semen extracts as an active ingredient for promoting the differentiation of adipocyte in human mesenchymal stem cell is provided to promote differentiating the adipocyte from a human mesenchymal stem cell to produce lipid droplet, enhance the electricity and the volume of skin and reduce wrinkles. CONSTITUTION: A composition for skin external application for promoting the differentiation of adipocyte contains Nelumbinis Semen extracts as an active ingredient. The composition promotes differentiating adipocyte from a mesenchymal stem cell. The mesenchymal stem cell is a human mesenchymal cell. The composition increases adipocyte tissue. For the total weight of the composition, a Nelumbinis Semen extract weighs ranging from 0.001 to 30%. The composition enhances the volume of skin and the elasticity of skin, and reduces skin wrinkles. A pharmaceutical composition for promoting the differentiation of a adipocyte cell contains Nelumbinis Semen as an active ingredient. A Nelumbinis Semen extract is administered from 0.001mg /kg /day-2000mg /kg /day. [Reference numerals] (AA) Relative revelation amount； (BB) Negative control group； (CC) Ligustri Fructus； (DD) Veratri Rhizoma Et Radix； (EE) Forsythiae Fructus； (FF) Nelumbo semen본 발명은 인간 중간엽줄기세포의 지방세포로의 분화를 촉진하는 조성물에 관한 것으로, 보다 상세하게는 연자육 추출물을 유효성분으로 함유하여 인간 중간엽줄기세포를 지방세포로 분화하는 것을 촉진시킴으로써 지방체 (Lipid droplet)를 생성하여 피부의 볼륨과 탄력을 증진시키고 주름을 개선시키는 조성물에 관한 것이다.
