The present invention discloses novel hybrid proteins that have both plasminogen activator and anti-thrombotic properties, including clot specific action, that renders these as highly advantageous for the treatment of circulatory disorders involving fibrin clot formation due to underlying tissue damage in the blood vesels leading to myocardial infarction, strokes etc. Also disclosed are new proteins, and methods of obtaining the same, that help to dissolve blood clots by activating plasminogen in a plasmin or thrombin dependent manner and also inhibit both the activity and generation of thrombin through the intrinsic pathway of blood coagulation.本發明揭示新穎的雜合蛋白質,其具有胞漿素原活化因子以及包括血塊特異性作用的抗血栓特性兩者,賦予雜合蛋白質非常有利於治療涉及因為血管內在組織損傷致使血纖維蛋白血塊形成而造成心肌梗塞、中風等的循環疾病。本發明亦揭示新穎的蛋白質及獲得該等蛋白質的方法,其藉由以胞漿素或凝血酶依賴型的方式活化胞漿素原而有助於溶解血塊,並且透過內源性凝血路徑抑制凝血酶的活性以及生成。
