The present invention provides means and methods for delivering a predetermined volume of a substance, within at least one body cavity of a subject, comprising a predefined volume for containing the predetermined volume of the at least one substance； a delivery end for placement in proximity to the body cavity； the delivery end comprises at least one orifice of diameter D [mm]； a valve mechanically connectable to the container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which the valve enables delivery of predetermined volume Vsub [ml] of the substance； and, (ii) an INACTIVE CONFIGURATION, in which the valve prevents delivery of the predetermined volume Vsub [ml] of the substance from the container to the body cavity； and a fluid tight chamber configured to contain predetermined volume Vgas [ml] of pressurized gas at a predetermined pressure, Pgas [barg].
