Disclosed are cosmetic compositions comprising lysed adipose tissue. The lysed adipose tissue contains no live cells. The cosmetic compositions can be formulated into topical formulations. Also disclosed are methods of making and using the cosmetic compositions comprising lysed adipose tissue. The cosmetic compositions can be made by obtaining fat tissue from a subject, lysing the fat tissue and combining the lysed fat tissue with a topical base. The cosmetic compositions can be used to rejuvenate or enhance skin.
