The U.S.A. as represented by the Secretary, Department of Health and Human Services;Yale University
发明人:
申请号：
EP16709158.6
公开号：
EP3242661B1
申请日:
2016.01.05
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule of formula II that selectively binds to and stabilizes G-quadruplex DNA in the promoter of thec-MYCgene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.
