The United States of America; as represented by the Secretary; Department of Health and Human Servic
发明人:
John Schneekloth, JR.,John Simmons,Kenneth Felsenstein,Beverly Mock,Lindsey Saunders,David Calabrese,Elena Leon
申请号：
US16835102
公开号：
US20200308128A1
申请日:
2020.03.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.
