ACHAMPETA RATHAN PRASAD,TIMOTHY DAVID GROSS,JANAKIRAM RAO CITINENI
申请号：
MX2012005235
公开号：
MX2012005235A
申请日:
2010.11.04
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
Provided herein are process for the preparation of N-(5-ferf-butyl-isoxazol-3-yl)- N-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,l-fe][l,3]benzothia zol-2-yl]phenyl}urea, or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof. N-(5-tert- Butyl-isoxazol-3-yl)-N-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[ 2,l-&][l,3]benzo- thiazol-2-yl]phenyl}urea is useful for treating, preventing, and/or managing diseases or conditions, including but not limited to, proliferative diseases, FLT-3 mediated diseases, and cancers. N-(5-ferf-Butyl-isoxazol-3-yl)-N-{4-[7-(2-morpholin-4-yl- ethoxy)imidazo[2,l-&][l,3]benzothiazol-2-yl]phenyl}urea is represented by the structure:.En la presente se provee un proceso para la preparación de N-(5-ter-butil-isoxazol-3-il)-N-{4-[7-(2-morfolin-4 -il-etoxí)imidazo-[2,1-b][1,3]benzotiazol-2-il]feni}urea, o una sal, solvato, hidrato o polimorfo farmacéuticamente aceptable de la misma. N-(5-ter-butil-isoxazol-3-iI)-N-{4-[7-(2-morfoIin-4-iI- etoxi)midazo-[2,1-b][1,3]-benzotiazol-2-il]fenil}urea es útil para tratar, prevenir y/o administrar enfermedades ocondiciones, incluyendo pero sin limitación a, enfermedades proliferantes, enfermedades mediadas con FLT-3, y cánceres. N-(5-ter-butil-isoxaz ol-3-il)-N-{4-[7-(2-morfoIin-4-il-etoxi)-imidazo-[2,1-b][1,3]ben zótiazol-2-iI]fenil}urea es representado por la estructura mencionada.
