The present invention provides a novel quinoline derivative inhibitor having the structure represented by the following general formula (I). The compound of the present invention can selectively inhibit the tyrosine kinase TAM family/and CSF1R kinase and can be used in the TAM family Kinase/and CSF1R kinase receptor and/or its ligand abnormal expression mediated disease treatment and/or prevention. Furthermore, the compounds of the present invention can be used to treat and/or prevent related diseases caused by NTRK, more specifically It can be used to treat and/or prevent drug-resistant related diseases caused by NTRK mutations. The definition of each group is shown in the specification.本發明提供一種新型的喹啉衍生物抑制劑，其具有下述通式(I)所示的結構，本發明的化合物可選擇性抑制酪胺酸激酶TAM家族/和CSF1R激酶，可用於TAM家族激酶/和CSF1R激酶受體和/或其配體異常表達所介導的疾病治療和/或預防，進而，本發明的化合物可以用於治療和/或預防由NTRK引發的相關疾病，更具體而言，可以用於治療和/或預防由NTRK突變產生的耐藥型的相關疾病。各基團定義如說明書所示。
