BAKER, THOMAS MATTHEW,FYFE, MATTHEW COLIN THOR,HARBOTTLE, GARETH WILLIAM,HASIMBEGOVIC, VEDRAN,MEGHANI, PREMJI,RIGBY, AARON,SAMBROOK-SMITH, COLIN,THOM, STEPHEN MALCOLM
申请号：
TW103112073
公开号：
TW201529556A
申请日:
2014.04.01
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
There are provided compounds of formula I, wherein R<；SP>；1A<；/SP>； to R<；SP>；1E<；/SP>；, R2 to R5, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes； Syk kinase； and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.本發明提供式I化合物，□其中R1A至R1E、R2至R5、L和X1至X3具有說明中所給予之意義，該等化合物具有抗發炎活性(例如透過抑制下列成員之一或二者：p38促分裂原活化蛋白激酶酵素之家族；Syk激酶；及酪胺酸激酶之Src家族成員)和具有於治療(包括於醫藥組合，尤其時於治療發炎性疾病，包括肺、眼和腸之發炎性疾病)的用途。
