Kevin Joly;Stuart Thomas Onions;William Garth Rapeport;Catherine Elisabeth Charron;Peter Strong;Kazuhiro Ito;Peter John Murray;John King-Underwood;Jonathan Gareth Williams
发明人:
Kazuhiro Ito,Peter Strong,William Garth Rapeport,Peter John Murray,John King-Underwood,Jonathan Gareth Williams,Stuart Thomas Onions,Kevin Joly,Catherine Elisabeth Charron
申请号:
US13139010
公开号:
US08299074B2
申请日:
2009.12.11
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present disclosure relates to compounds of formula (I):which are inhibitors of p38 mitogen-activated protein kinase enzymes, particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.