A computer-implemented system and method for fast, reliable, and automated embodiments for using a multi-resolution edge flow approach to vascular ultrasound for intima-media thickness (IMT) measurement. Various embodiments include receiving biomedical imaging data and patient demographic data corresponding to a current scan of a patient； checking the biomedical imaging data in real-time to determine if an artery of the patient has a calcium deposit in a proximal wall of the artery； acquiring arterial data of the patient as a combination of longitudinal B-mode and transverse B-mode data； using a data processor to automatically recognize the artery； using the data processor to calibrate a region of interest around the automatically recognized artery； automatically computing the weak or missing edges of intima-media and media-adventitia walls using edge flow, labeling and connectivity； and determining the intima-media thickness (IMT) of an arterial wall of the automatically recognized artery.
