A computer-implemented system and method for intima-media thickness (IMT) measurements using a validation embedded segmentation method. Various embodiments include receiving biomedical imaging data and patient demographic data corresponding to a current scan of a patient checking the biomedical imaging data in real-time to determine if an artery of the patient has a calcium deposit in a proximal wall of the artery acquiring arterial data of the patient as a combination of longitudinal B-mode and transverse B-mode data using a data processor to automatically recognize the artery by embedding anatomic information using the data processor to calibrate a region of interest around the automatically recognized artery automatically computing the weak or missing edges of intima-media and media-adventitia walls using edge flow, labeling and connectivity and determining the intima-media thickness (IMT) of an arterial wall of the automatically recognized artery.
