The invention relates to a method of fabricating a personalized positioning guide (10) for positioning at least one member on a distal end (I) of a femur or on a proximal end of a tibia of a patient, the method including the step (200) of modeling the desired end as a three-dimensional virtual model on the basis of at least one medical image of said end. According to the invention, the method comprises the steps of: - positioning (300) a three-dimensional predetermined virtual positioning guide relative to the virtual model of the end . virtually removing (400) from the predetermined virtual positioning guide any portion thereof that is intersected by the virtual model of the end in order to obtain a personalized virtual positioning guide and - fabricating (500) the personalized positioning guide by powder sintering on the basis of the personalized virtual positioning guide. Fig.1 20a p 20b Take a medical 100 J image of the end 20d Model the end 200 as a virtual 3D model 20c Position a 3D predetermined 300 virtual positioning guide Virtually remove any intersected portion 400 to obtain a personalized virtual positioning guide Fig.2 Fabricate the personalized 500 positioning guide
