Luke Green;Georg Jaeschke;Wolfgang Guba;Eric Vieira;Lothar Lindemann;Heinz Stadler;Synese Jolidon
发明人:
Luke Green,Wolfgang Guba,Georg Jaeschke,Synese Jolidon,Lothar Lindemann,Heinz Stadler,Eric Vieira
申请号：
US12964785
公开号：
US08586581B2
申请日:
2010.12.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to ethynyl compounds of formulawherein X, Y, Z, and R4 are as defined hereinor to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) and they are therefore useful for the treatment of diseases related to this receptor.
