Luke Green,Wolfgang Guba,Georg Jaeschke,Synese Jolidon,Lothar Lindemann,Heinz Stadler,Eric Vieira
申请号：
US14055047
公开号：
US08933094B2
申请日:
2013.10.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to ethynyl compounds of formulawherein X, Y, Z, and R4 are as defined hereinor to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) and they are therefore useful for the treatment of diseases related to this receptor.
