As for this invention, regarding the chemical compound formula (i), < Conversion 1 > In order these chemical compounds, and those constituents, to prepare the intermediate field and the derivative, and ankylosing spondylitis, ateromu arteriosclerosis and the arthritis (glenoid riumachi, the infection Characteristic arthritis, the child arthritis, the dry Ichthyosis Characteristic arthritis and the reactivity arthritis), the bone-related disease (those which it is related to bone formation are included), the breast cancer (include those of non responsiveness in anti- estrogen medical therapy), the cardiovascular disturbance and the cartilage-related disease (those which it is related to the cartilage damage/loss, cartilage denaturation, and cartilage formation), cartilage strange formation and the cartilage sarcoma, the chronic back section damage and the chronic bronchitis, chronicityThe inflammation Characteristic windpipe disease and the chronic blockade Characteristic lung disease, the disease of diabetes and energy homeostasis, the gout and the false gout, lipid fault, metabolic syndrome, the occurring frequently Characteristic marrow swelling, obesity and the deformans arthritis, the bone formation incomplete symptom, bone Characteristic bone transfer, the osteomalacia and the osteoporosis symptom, the pajietsuto illness, the gearwheel lap the illness and the riumachi Characteristic occurring frequently myalgia, lighter/writer syndrome, the repetition motion damage, the high blood glucose, rise, and insulin resistance of blood glucose value are included, but it regards the manner for remedying the condition which is not limited in these.本発明は、式(I)の化合物に関し、【化1】これらの化合物、並びにそれらの組成物、中間体及び誘導体を調製するため、並びに強直性脊椎炎、アテローム性動脈硬化、関節炎(関節リウマチ、感染性関節炎、小児関節炎、乾癬性関節炎、反応性関節炎)、骨関連疾患(骨形成に関連するものを含む)、乳癌(抗エストロゲン療法に非応答性のものを含む)、心血管障害、軟骨関連疾患(軟骨損傷/損失、軟骨変性、及び軟骨形成に関連するもの)、軟骨異形成、軟骨肉腫、慢性的な背部損傷、慢性気管支炎、慢性炎症性気道疾患、慢性閉塞性肺疾患、糖尿病、エネルギー恒常性の疾患、痛風、偽痛風、脂質障害、メタボリックシンドローム、多発性骨髄腫、肥満、変形性関節炎、骨形成不全症、溶骨性骨転移、骨軟化症、骨粗鬆
