The present invention provides compounds of Formula I or a pharmaceutical salt thereof; methods of treating osteoarthritis and the pain associated with osteoarthritis using the compounds; and processes for preparing the compounds.本發明提供式I化合物或其醫藥鹽;使用該等化合物治療骨關節炎及與骨關節炎相關之疼痛之方法;及製備該等化合物之方法。