NOUVEAU COMPOSÉ DÉRIVÉ DE SPIROQUINONE, SON PROCÉDÉ DE PRODUCTION, ET COMPOSITION PHARMACEUTIQUE LE CONTENANT EN TANT QUE PRINCIPE ACTIF POUR PRÉVENIR OU TRAITER DES TROUBLES NEUROLOGIQUES
Gachon University of Industry-Academic Cooperation Foundation;Gil Medical Center
发明人:
申请号：
EP17849145.2
公开号：
EP3395804A4
申请日:
2017.09.08
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention relates to a novel spiroquinone derivative compound, a production method thereof, and a pharmaceutical composition for preventing or treating neurological disorders which contains the compound as an active ingredient, and it has been confirmed that the novel spiroquinone derivative compound according to the present invention, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof may excellently suppress 'microglial activation' and shows excellent inhibition activity against acetylcholinesterase, JNK1, JNK2 and JNK3, and in addition to this, significant enzyme inhibition activity has been confirmed in a neurological diseases-related enzyme group, RIPK5, CDK3/cyclin E, PKN2/PRK2, Haspin, STK25/YSK1, ARK5/NUAK1, PKCb2, CDK2/cyclin O, DAPK1, PKCa, CDK1/cyclin B, MST3/STK24 and TLK1 and it has been confirmed that cell death suppression effect may be exhibited, and thus the novel spiroquinone derivative compound according to the present invention, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof can be usefully used for a pharmaceutical composition for preventing or treating neurological disorders or health functional food composition for preventing or improving neurological disorders by being contained therein as an active ingredient.
