NOUVEAU COMPOSÉ DÉRIVÉ DE SPIROQUINONE, SON PROCÉDÉ DE PRODUCTION, ET COMPOSITION PHARMACEUTIQUE LE CONTENANT EN TANT QUE PRINCIPE ACTIF POUR PRÉVENIR OU TRAITER DES TROUBLES NEUROLOGIQUES
(의료)길의료재단;가천대학교 산학협력단;GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION;GIL MEDICAL CENTER
发明人:
KIM, Mi-hyun,김미현,KIM, Sun Yeou,김선여,ARRAMSHETTI, Venkanna,알람세티벤카나,KIM, Kang,김강,CHO, Kyohee,조교희,LAMA, Prema Dhorma,라마프레마 도르마,LEE, Sang-Yoon,이상윤
申请号：
KRKR2017/009909
公开号：
WO2018/048261A1
申请日:
2017.09.08
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a novel spiroquinone derivative compound, a production method thereof, and a pharmaceutical composition for preventing or treating neurological disorders which contains the compound as an active ingredient, and it has been confirmed that the novel spiroquinone derivative compound according to the present invention, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof may excellently suppress 'microglial activation' and shows excellent inhibition activity against acetylcholinesterase, JNK1, JNK2 and JNK3, and in addition to this, significant enzyme inhibition activity has been confirmed in a neurological diseases-related enzyme group, RIPK5, CDK3/cyclin E, PKN2/PRK2, Haspin, STK25/YSK1, ARK5/NUAK1, PKCb2, CDK2/cyclin O, DAPK1, PKCa, CDK1/cyclin B, MST3/STK24 and TLK1 and it has been confirmed that cell death suppression effect may be exhibited, and thus the novel spiroquinone derivative compound according to the present invention, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof can be usefully used for a pharmaceutical composition for preventing or treating neurological disorders or health functional food composition for preventing or improving neurological disorders by being contained therein as an active ingredient.La présente invention concerne un nouveau composé dérivé de spiroquinone, un procédé de production de celui-ci, et une composition pharmaceutique qui contient le composé en tant que principe actif, pour prévenir ou traiter des troubles neurologiques, et il est confirmé que le nouveau composé dérivé de spiroquinone selon l'invention, un stéréoisomère de celui-ci, ou un sel pharmaceutiquement acceptable de celui-ci peut supprimer de manière excellente 'l'activation microgliale' et présente une excellente activité d'inhibition contre l'acétylcholinestérase, JNK1, JNK2 et JNK3, et en plus de cela, une activité d'inhibition d'enzyme significative est confirmée dans un groupe d'enzymes ass
