Youn Ho Han;Ji Min Kim;Se-Won Kim;Dong-Sik Jung;Jung Ho Kim;Se-Nyum Kim;Guo Fan Jin;Dae-Pil Kang;Sung-Ho Park;Jhi Zheng
发明人:
Se-Won Kim,Jung Ho Kim,Se-Nyum Kim,Dae-Pil Kang,Youn Ho Han,Guo Fan Jin,Dong-Sik Jung,Sung-Ho Park,Ji Min Kim,Jhi Zheng
申请号：
US13392024
公开号：
US20120149707A1
申请日:
2011.04.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to an alpha-arylmethoxyacrylate derivative, a preparation method thereof and a pharmaceutical composition comprising the same, and the alpha-arylmethoxyacrylate derivative is inhibitory of HIF, which plays an important role in the regulation of genes associated with energy metabolism, vasomotion, angiogenesis and apoptosis and in the response of cells under hypoxic conditions, so that it can be used for preventing or treating of diseases such as cancer, arthritis, psoriasis, diabetic retinopathy and macular degeneration.
