Александр Юрьевич,Андрей Павлович,Максим Валерьевич,Антон Николевич,Андрей Владимирович,Дмитрий Александрович,Сергей Валериевич,Игорь Павлович,Равиль Авгатович,Александр Михайлович
申请号：
EA201890805
公开号：
EA201890805A1
申请日:
2016.11.29
申请国别(地区):
EA
年份:
2018
代理人:
摘要：
the invention belongs to the biotechnology and, in particular,can be used in medicine and the pharmaceutical industry for the manufacture of pharmaceutical treatment for b cell diseasesdepletion of b cells or slow down the development of pathological conditions associated with b - \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u043c\u0438 violations.\u0431\u0438\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u043e\u0435 antibody, specific \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0435\u0435\u0441\u044f with cd3 and cd19, consists of two united \u0434\u0438\u0441\u0443\u043b\u044c\u0444\u0438\u0434\u043d\u044b\u043c\u0438 connections chain.each chain contains \u0432\u0430\u0440\u0438\u0430\u0431\u0435\u043b\u044c\u043d\u044b\u0435 domains of light and heavy chains of antibodies against cd3 and cd19, \u043b\u0438\u043d\u043a\u0435\u0440\u043d\u044b\u0435 sequence\u0448\u0430\u0440\u043d\u0438\u0440\u043d\u0443\u044e region of immunoglobulin igg and a constant region fc domain of igg igg.an antibody produced by recombinant dna technology using \u043a\u043e\u0434\u0438\u0440\u0443\u044e\u0449\u0435\u0439 antibody containing nucleic acid and \/ or its vector imposed claix \u0442\u043a\u0443 - master.method of obtaining antibodies includes, at least, the cultivation of cells is the master and the target product. the cleaning method includes at least the phase chromatography.antibody used for the treatment of b cell diseases, depletion of b cells or the slowing of development condition, associated with b - \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u043c\u0438 n \u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u043c\u0438.the pharmaceutical composition comprises the antibody and \u0444\u0430\u0440\u043c\u0430\u0446\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438 acceptable carrier.method of treating these diseases includes the introduction of a patient in need of it, \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447
