Shawn P. Walsh,Brian Cato,Jessica L. Frie,Dooseop Kim,Alexander Pasternak,Zhi-Cai Shi
申请号：
US14647257
公开号：
US20150299198A1
申请日:
2013.11.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides compounds of Formula Iand the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
