Inhibitors of the renal outer medullary potassium channel

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专利权人:

Merck Sharp & Dohme Corp.

发明人:

Pasternak, Alexander,Blizzard, Timothy,Chobanian, Harry,De Jesus, Reynalda,Ding, Fa-Xiang,Dong, Shuzhi,Gude, Candido,Kim, Dooseop,Tang, Haifeng,Walsh, Shawn,Pio, Barbara,Jiang, Jinlong

申请号：

AU2012299227

公开号：

AU2012299227A1

申请日:

2012.08.16

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/