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リスペリドンを含有する口腔内崩壊錠剤および苦味抑制製剤
专利权人:
塩野義製薬株式会社
发明人:
豊田 智淳,今元 千絵子,友田 宜孝
申请号:
JP2008552107
公开号:
JP5275815B2
申请日:
2007.12.25
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
Disclosed are: an orally disintegrating tablet and a bitter-blocking preparation and each of which comprises risperidone. It is found that an orally disintegrating table having good disintegration property and ensured hardness can be produced by compressing and shaping a powder comprising risperidone, crystalline cellulose, an inorganic excipient, carmellose, and a lubricating agent in an amount of 0.8 wt% or less, preferably 0.5 wt% or less and more preferably 0.1 wt% or less per one tablet. Specifically disclosed are: a powdery/granular preparation produced by granulating an excipient and/or a disintegrating agent with a solution having a bitter-blocking base material dissolved and/or suspended therein and also having risperidone having a solubility in water of 1 g/mL or less (at 20C) dissolved or suspended therein and a tablet produced by tabletting the powdery/granular preparation. The powdery/granule preparation and the tablet can block a bitter taste of risperidone.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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