PROBLEM TO BE SOLVED: To provide a tosufloxacin tosylate-containing granular solid preparation presenting good suspension tendency, mitigated in unpleasant tastes such as astringency, excellent in the medicaments elution tendency and absorbability in the digestive tracts, good in the uniformity of content by granular sizes, excellent in handleability and productivity and having sharp granular distribution.SOLUTION: The tosufloxacin tosylate-containing granular solid preparation presents good suspension tendency into water, syrup or the like, is mitigated in unpleasant tastes such as astringency, is mitigated in foamability when made into an aqueous form, can be takable in its prescribed amount accurately, thus is useful for infants and eldery people. Furthermore, this preparation is also useful as a preparation excellent in terms of administration management with slight content variation and in handleability regarding weighing and aliquot packaging operations and the like and productivity, because of being excellent in the medicaments elution tendency and absorbability in the digestive tracts and in the uniformity of content by granular sizes and having sharp granular distribution.COPYRIGHT: (C)2008,JPO&INPIT【課題】良好な懸濁性を示し、渋味などの不快味が軽減され、消化管内での薬物の溶出性および吸収性に優れ、かつ、粒度別含量の均一性に優れ、取扱性および生産性に優れるシャープな粒度分布を示すトシル酸トスフロキサシンを含有する粒状固形製剤を提供すること。【解決手段】本発明のトシル酸トスフロキサシン含有粒状固形製剤は、水やシロップなどへの良好な懸濁性を示し、さらに渋味などの不快味が軽減され、製剤を水剤化の際の起泡性などが軽減され、正確に規定量を服用でき、小児や高齢者向けの製剤として有用である。また、本発明の製剤は、消化管内での薬物の溶出性および吸収性に優れ、優れた粒度別含量の均一性およびシャープな粒度分布を示すことにより、含量変動が少なく投薬管理の面に優れ、秤量や分包作業などの取扱性および生産性に優れた製剤としても有用である。【選択図】なし
