KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
Jin Woo Kim,Nam-Suk Kim
申请号：
US15159739
公开号：
US09968651B2
申请日:
2016.05.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition for the regeneration of nerves comprising Vax protein as an active ingredient. Vax1 is secreted in the ventral hypothalamus (vHT) explant separated from a mouse. The secreted Vax1 combines with extracellular sugar group of heparan sulfate proteoglycans (HSPGs) existing in retinal ganglion cell (RGC) axon of the retinal explant co-cultured so as for the complex invades into axonplasm. Then, the Vax1 conjugated with the sugar group activates the local protein synthesis to accelerate the growth of retinal ganglion cell axon. In some embodiments, Vax protein or a nucleic acid encoding the protein, can be used in a pharmaceutical composition for the regeneration of nerves.
