PROBLEM TO BE SOLVED: To provide a suppository suppressed in cracking or debonding from the boundary surface in a multilayered suppository preparation.SOLUTION: The suppository preparation composition characterized in that, in a suppository having a rectum upper part mobile layer and rectum lower part resident layer, either one or both of the layers is incorporated with a paraffin-based hydrocarbon.COPYRIGHT: (C)2010,JPO&INPIT【課題】多層坐薬製剤における境界面からの製剤の割れもしくは剥離を抑制した坐剤の提供。【解決手段】直腸上部移動性層と直腸下部滞留性層とを有する坐剤において、いずれか一方又は両方の層にパラフィン系炭化水素を含有させたことを特徴とする坐剤製剤組成物。【選択図】なし
