David V. Schaffer,Leah C. Byrne,Timothy P. Day,John G. Flannery
申请号：
US16486681
公开号：
US20200121746A1
申请日:
2018.06.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater ability to cross barriers between intravitreal fluid and retinal cells, and thus greater infectivity of a retinal cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.
